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KMID : 0361520000110030254
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Korean Journal of Psychopharmacology
2000 Volume.11 No. 3 p.254 ~ p.261
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The Effect of Polygalasaponins in Polygalae Tenuifolia on Apomorphine-Induced Hyperlocomotions in Mice
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정인원/In-Won Chung
김운택/오원근/안종석/이현선/김용식/박주배/이창인/Woon-Taek Kim/Won-Keun Oh/Jong-Seog Ahn/Hyun-Sun Lee/Yong-Sik Kim/Joo-Bae Park/Chang-In Lee
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Abstract
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Objective: This study was to investigate in vivo antidopaminergic activities of
polygalasaponins which included in the roots of Polygalae tenuifolia, one of the natural
plants prescribed to treat psychotic disorders in traditional medicine.
Methods: The chemical separations were conducted by chromatographies with various
columns and the chemical structures were identified using spectroscopy, NMR and so
on. The apomorphine-induced stereotyped behaviors and climbing behaviors in mice as
animal models of psychotic disorders were applied to explore the antidopaminergic
activity.
Results: The active compounds with antidopaminergic effects in the roots of Polygalae
tenuifolia were identified as polygalasaponin A-D. The polygalasaponins showed to
suppress the apomorphine-induced stereotyped behaviors and climbing behaviors in
dose-related fashions.
Conclusion: This study suggests that polygalasaponins might have antipsychotic
activities. The natural products need to be explored extensively as sources of new
medications in psychiatric fields. Further explorations for chemical and pharmacological
properties of polygalasaponins are required.
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